Hair salons near me open now

Can you take a deep breath and forgive yourself?

2011.08.27 08:20 Ingish Can you take a deep breath and forgive yourself?

calmhands is a community based around kicking the habit of kicking compulsive habits such as nail biting and nail picking. The goal of the sub is for you to be able to share resources, photos, and accountability with a lovely community that wants to do the same. Together we got this!

2015.12.30 22:26 CaptainHair59 /r/CaptainHair59 Go one, go all, Captain Hairs 1-58!

Hopefully the other CaptainHair\s will leave me alone here...

2016.06.16 18:21 Look for a group in Shattered Skies

Look for a group in Shattered Skies

2023.06.08 11:06 issa-newbie What to do/say when someone is feeling lonely

I have a guy friend who is dealing a lot in his personal life, like father being irresponsible and mentally abusive to his mother, brother doesn't care about his mother's health, he lives in different city from his family, not able to focus on work and studies, doesn't get to eat proper food daily and last but not the least possibility of not getting married to the love of his life. I know it's too much and I'm worried about him. He's an introvert doesn't open up but he's very comfortable with me and tells me everything. We have been friends for years.
Now my main concern here is he yesterday said I feel alone and helpless, he wants to leave everything and go something far from all this. I'm really really worried. What are all the things I can do or tell him that'll make him feel less lonely and more motivated.
submitted by issa-newbie to TwoXIndia [link] [comments]

2023.06.08 11:06 suburban_mom_ What’s it like being in a relationship and having IBS?

In the past I’ve found that when I was in a really toxic relationship my IBS would flare up towards the end but I didn’t know it was IBS at the time. After drinking lactulose and sipping some hot water right now, I’m wondering what IBS looks like in a relationship. Gentle tummy rubs accompanied with flatulence? I’ve opened up about my IBS with a past FWB when I was going through an episode and felt embarrassed but he reassured me that most hot people have stomach problems. I thought this was funny but I still hid myself from him.
submitted by suburban_mom_ to ibs [link] [comments]

2023.06.08 11:04 bitchinwitchy Witnessed strange lights

Witnessed strange lights
Back at the end of last year I had a series of weird things happen that I’m trying to process/get some insight on. It started a few months after I began experimenting with magic mushrooms. I had taken a fair amount of mushrooms before these events happened and hadn’t experienced anything out of the ordinary even taking probably close to 7 grams in a period of 2 hours or so - and did not have too heavy of a trip) I decided to start dosing before work which I figured would be chill as (like I said) I had already experimented and did not get visuals or feel particularly out of control. In fact it felt like I was a lot more in tune with my surroundings even driving and stuff.
With that said, I started taking about 1 gram or so every couple days and around this time is when I met Sue - a homeless woman who would come into our coffee shop almost daily while I was barista-ing. I was immediately intrigued by her and we became fast friends. She told me she was 67, half miwok Indian, half polish, and she was always dressed in a colorful outfit, beautiful rings, with her nails painted. She’d tell me about her tarot readings and we’d share a cigarette while I was on break. It was clear when I met her she probably had some type of mental illness going on because she would sometimes talk loudly about arch angel michael, money from god, and things that didn’t make a lot of sense to me, but I tried to remain open minded and curious with her. I even offered her mushrooms but she refused saying she had “enough spiritual stuff going on in her life.”
One day, after a particularly interesting conversation with Sue, I disappeared off to run an errand for my boss, when I came back Sue was gone and my boss handed me a tattered book. it was “A Life in Drama” a biography on Shakespeare or something of the like, and the outside of the book was covered in cryptic pen drawings like I’d never seen before. There was an inscription “June Sue I learn from you!” Which immediately brought me back to the first day I met her. She had drawn me and I had told her loved that I loved her name - she told me I should add it to my name and I agreed with her.
“your guardian anglebirth” it read. And there was a sparrow hawk, trees, a ship all sort of in abstract pen drawing. On the front, in small ink, less than an inch, there was an almost abstract looking shape and in the center was the word “love” - she never told me what the shape was as she didn’t remember drawing it but later my therapist suggested it as a picnic basket. Anyway, a few days later I went and had it tattooed on my arm because I loved it.
I was in the process of quitting my job around this time so I wasn’t seeing Sue as often which prompted me to think about when to go visit her. I was in no hurry to show her, I knew when the time was right I would go.
A few afternoons later, after taking about a gram of mushrooms I bought 200$ worth and then went to see her. It was around this time that day I started hearing voices I thought at the time were god and the mushrooms themselves.
It’s been a while since this all happened so my memory is a bit blurry, though I did write down most of what happened shortly thereafter. Anyways, there was something about Sue that I trusted. I really wanted to show her my mushrooms so I took her to my trunk. All I remember is sitting in the back of the trunk with her and all of a sudden these crazy lilac purple lights start shining down on me like I’m on a stage? This is in broad daylight on the street. I remember there was like a little noise they made I think, and it felt like i was in the twilight zone. It was so bizarre - I’ve never experienced anything remotely like it. And the only place they really shown down on was my face and neck (where I had lots of acne). As I’m like, what the fuck is going on Sue looks over and says something along the lines of “many gifts are coming to you.” ( like I said, never experienced ANY visions before and having Sue acting like she saw the light too makes me feel like something weird is going on. )
Later on back in her tent all of a sudden I start experiencing the most insane pain but it’s not physical. To this day I don’t know how to describe it but I was deeply uncomfortable to the point where I am SCREAMING in this woman’s tent and she’s telling me to quiet down so the cops don’t come and commit me. After that she gave me water, food, and it kind of felt like she could read my mind which is a phenomena I experienced a lot the next few days. Everything I needed she provided. I was completely depleted and weak. She was yelling at mysterious powers saying “earthangel June (me) does not deserve this!!” She told me I had been divinely poisoned by the mushrooms because I had not blessed them before ingesting them. Later that night she also tells me that her tarot cards told her a young woman would come to visit her and that I was she.
I slowly came down a bit. Sue offered for me to spend the night, but I knew I wanted to go back home, though it was past midnight when I got home. I don’t remember much of the mundane time between - The next morning I woke and headed back to her where I spent another full day and find out both me and my dads debit cards aren’t working, and Sue is unsurprised (I’m starting to believe in this weird matrix of energy she’s talking about and feel like I’m targeted when I’m around her, or that she has some sort of bad luck) She dropped many lessons about God, energy, and demons and doing readings for people, which I started to come around to that day. I noticed that even people I would have avoided or felt unsafe with on my own, respected her or at least stayed away from her. I have a vivid memory of her saying “watch this!” And then with a lasso motion zapping me energetically so hard it makes me wince. That day Sue piled heaps of designer clothes into the trunk of my car which had been donated by the wealthy. As she does this she handed me a piece of paper that had printed on it what I later find out is a piece of “They’re made out of meat” by Terry Bison.
They're made out of meat." "Meat?" "Meat. They're made out of meat." "Meat?" "There's no doubt about it. We picked several from different parts of the planet, took them aboard our recon vessels, probed them all the way through. They're completely meat." "That's impossible. What about the radio signals? The messages to the stars." "They use the radio waves to talk, but the signals don't come from them. The signals come from machines." "So who made the machines? That's who we want to contact." "They made the machines. That's what I'm trying to tell you. Meat made the machines." "That's ridiculous. How can meat make a machine? You're asking me to believe in sentient meat." "I'm not asking you, I'm telling you. These creatures are the only sentient race in the sector and they're made out of meat."
She asked me if I remember the guy who comes into our coffee shop with a helmet on sometimes, and I say yes, and she suggests he might be an alien because she found this on the table after he left.
It is clear to me now that day, November 29th I was beginning to open the question - who am I? I’d been curious of my lineage but also potential past lives.
I went back home that night and At 2am still hopped up from the mushrooms I put on some clothes Sue had given me and got in my car feeling called to drive aimlessly. After 15 minutes I reached a glowing indigo Hyatt sign and immediately pulled in. I had just quit my Hyatt job and figured at the very least it could be a job opportunity for me there (as I had just quit working at a Hyatt)
When I got there a short, beautiful, and politely unassuming woman greeted me at a desk amidst a beautiful well light welcoming room. She appeared to be completely alone and I immediately felt safe and welcomed by her, though I quickly revealed I wasn’t quite sure why I had intended to show up to the hotel. I went with the flow, the woman asked me if I’d rather be at a cheaper Hyatt down the road and I immediately refused. I went to use the restroom, when I came out there was a single strangely menacing, yet friendly guard.
I hung around aimlessly, asking if I could sit on the marble countertops - dressing and acting as if completely in a trance and unashamed of myself and still high on mushrooms. The woman discouraged me because I think I would’ve been seen on the cameras. Instead, I sat down on a comfortable couch and began to converse with her. I felt She was gentle and good hearted but I also felt we were deeply on the same wavelength somehow. She asked me about my life, and I vaguely mentioned it was changing deeply - referring to my experiences with Sue and Psylocibin, without mentioning them. I stared deeply and intently at her, listening to her talk a bit, while in my head I asking questions in my mind “who will I have children with?” “Where do I belong in this life?” Feeling desperate and exhausted by those questions.
The woman picked up her can of bright red coke with both hands, 3 fingers facing up on either side, and told me the answers would come to me in a dream. I broke out into surprised, joyful, and astounded laughter and exclaimed “holy shit!” Because in my state it seemed like she was totally clued into what I had going on. Then she said what translated to my trancelike state as something along the lines of, “this isn’t my first rodeo.”
At this point, I’m still in an altered state and believe this hotel is somehow heaven?
Once our conversation was over, we took the elevator up together, (I think she knew I was high and wanted to make sure nothing went wrong.) I asked for a room on the 4th floor, but she said an entire childrens soccer team was residing and that she’d give me the third. I laughed and thanked her. She asked me a few questions, I don’t remember what they were, but they were easy to answer and I only remember her saying “we just want to make sure what you took was clean.” I’m not sure what she meant by this looking back, but in the moment I thought she was asking me because there was something she didn’t want to share with me if the mushrooms I had taken weren’t safe. Like she wanted to check my purity or something (though I could be imagining that)
She lead me to my room, said I could leave the door open, with the latch, when I wanted to come down, and did not give me a key and then she said that she’d be with me all night long.
I put my things down, and immediately began to look at myself in the luminescent hotel room mirrors feeling a deep pain and sadness. I slowly and delicately put my hair up, washed my face carefully, got undressed and began to massage lotion into my skin for some reason?
Then I looked in the mirror and began to squeeze the gunk out of my skin, believing that I am somehow ridding myself of ancestral curses - famine, disease, rape, pain. I started to form a story line around potential past lives. I’ll spare y’all the details of the rest of my episode because a lot of it still doesn’t make much sense to me. But besides the light I saw, it’s little coincidences that I keep coming back to in my mind that are so strange.
Like, The next day I get a haircut, the barber is an eclectic guy and mentions my evil twin sister (something Sue also did) for no apparent reason (I’ve never met the guy before) afterwards I go to the kava bar and immediately meet a random girl who also seems to be in the middle of a psychotic episode. She starts talking about conspiracy theories and stuff and she tells me she is secretly a native woman who just appears to be a black woman. Then she pulls out a pendulum and refers to it as “this thingy” I’m a bit surprised because the night before Sue had shown me how to use one to read yes, no and maybe.
I take my new friend Candace back home with me (she reveals to me she has another name she only shares when she feels safe) I don’t remember what it was but when I introduce her to one of my roommates as Candace he says “oh no it’s something more ancient than that” which I find really weird because he’s never met her before (how would he know she had a second name?) and it’s just a weird thing to say in general.
I forget I have a therapy appointment that day and am all of a sudden skeptical of my therapist, Candace briefly meets her and then tells me “she was divinely sent” which makes me feel less paranoid and I remember expecting her to say something of the like.
It’s also around this time I find 3 dead birds on a bike ride on the ground (3 different species) within exactly 11 minutes and they seem to stand out enough to maybe be trying to tell me something. I asked my friend who is a medicine woman to interpret the meaning, and it feels pretty on point to what happened looking back.
In retrospect, not necessarily everything I’ve shared means something extra-ordinary, but I’m curious to hear some other thoughts on what happened, and the context.
I put my things down, and immediately began to look at myself in the luminescent hotel room mirrors feeling a deep pain and sadness. I slowly and delicately put my hair up, washed my face carefully, undressed and began to massage lotion into my skin for some reason?
Then I looked in the mirror and began to squeeze the gunk out of my skin, believing that I was somehow ridding myself of ancestral curses - famine, disease, rape, pain. I started to form a story line around potential past lives.
I laid down in the bed, bluntly put, grabbed my vibrator, and spent hours with a voice in my head I believe to be the woman. She was gentle, wise and delicate, and when I touched myself I felt it was not me but her.
She told me things I wanted to understand about original biblical references, the creation of Adam and Eve, or whatever names they were, and I saw and felt at times, that I was birthing other creations amidst the quiet, deep intense, solitude of our connection. It was deeply lovely. I looked at the clock and had an innate sense our time was coming to an end. Completely naked and feeling nothing but gratitude, love, and wonder, I opened the curtains and looked out at the most beautiful cloudy sunrise. I felt I was looking directly at god and not a word had been said all night inside the room. It was one of the most beautiful things ID ever seen - I was truly in it, and I just knew.
I forgot, that when I had first checked into the room I had texted the man I was sleeping with, whom I loved, but was feeling confusion around as we were staying only casually connected. I regrettedly called him back (he had tried to call me earlier after I had sent him a series of cryptic texts like “some really cool shit is happening call me when you can.”) I asked him if I could come over, he said “I have some things to do today, can it wait?” I said “no” “he said I guess I can make the time then, or something along those lines.” Still in a complete trancelike state, I got in the car and frantically drove to his house without any real permission, which is painful to think about in retrospect.
When I got there, I unassumingly rang the doorbell and he happily let me in as if, or as I thought, he’d been expecting me.
I crawled into bed with him and felt safe again, like I had with Sue and with the woman whose name I had learned was Alexandria. I thought I could relax, but then immediately sex ensued again, and I felt both more and less control than I usually did when I was not in this strange state.
I don’t remember much except screaming and crying loudly, calling his name and telling him I loved him (which I had never done before) and I remember him saying it back to me.
I could feel my spiritual energy was so strong he was responsive to it which was terrifying as it was so new to both of us. In retrospect, I feel we were-him most of all, somewhat blind to what was happening. Sue had told me we had the power to hypnotize men, but I didn’t think I would be doing that so soon.
Before I knew it he asked me if I had a condom. I said no only in my car outside. And he pulled out what almost appeared to be a flaming red one directly after asking me if I had mine. I don’t remember putting it on or taking it off. I asked if he’d had sex with anyone else and he said “last week” which was strange and hurt me because I thought we had been sort of accidentally exclusive for the majority of our relationship together - later he revealed he had not had sex. I recall holding his hand and showing each other the birth of creation, me showing him love perhaps, feeling balls of light and darkness as stars circle each other before they explode. After that I only really remember being on top of him, me in complete control, asking him to cum, him saying “I can’t” and then having a massive horrible realization, looking him straight in the face and saying, “ohhhhh you’re the devil aren’t you? You’re beautiful. Oh my god you’re beautiful.” He looked so beautiful and I held his face. Then I was professing my love for him again and again and again even though my heart was breaking as I did because I somehow knew the face looking at me was not capable of love. The rest was a confusing blur. I don’t remember much about leaving him except that it hurt me probably more than the spiritual pain I had experienced in the tent. I felt completely and utterly alone, heart broken, and terrified. Rattled, and in a daze I pulled up my phone directions, and drove for what felt like 20 minutes until I saw a beautifully insane woman, head hung low, dressed in black, almost like a shadow, sitting on the curb, both feet in the road. I slowed down, rolled my window, and asked for Sue. She said yes she’s already at the place with the TV, and she said she wanted something in return. She went to reach for my Bluetooth adapter and without question, I handed it to her. I had learned not to be afraid to lose things, my love and life was the only thing that mattered to me.
I drove onward, got on the freeway, and in memory, passed exits I recognized over and over again driving for what felt like an hour, miserable and screaming and crying in pain and fear, windows rolled down wind recklessly pushing and pulling at me, and calling out for Sue, understanding I was time traveling. I remember most vividly seeing the words “Richard blvd” (the name of my exit to Davis” at least twice between sacramento exits. I attempted not to doubt, only to trust, I would arrive home, though I was terrified for my physical and spiritual lives.
I don’t remember much about arriving home. I only remember being deeply relieved to be somewhere familiar again.
I would stay in this state a few more days…until my parents pulled me out, I believed my mother had died and I felt such agony I was screaming in the room of my house, my roommates rushing in to comfort me. I was not in control enough of myself to remain on those realms in any capacity after the days I had been through. I needed to be recaptured reraptured in love only my family could give me. And I am forever grateful they took me home to them.
submitted by bitchinwitchy to Experiencers [link] [comments]

2023.06.08 11:02 not_irish_patrick We're joining the Reddit blackout from June 12th to 14th, to protest the planned API changes that will kill 3rd party apps

Hello dear /52book friends,
TL;DR: click me for a visual guide.
On May 31st, 2023, Reddit Inc announced changes to their API usage policy which, if enacted, will quite permanently shut down many, if not all, third party apps that a large number of Redditors use to access and enjoy their favorite communities - this one included.
One of the most critical changes to the API is that it is moving from a free to a paid model, resulting in expenses that developers of third party apps simply cannot afford. To put the price change in to context, Apollo, one of the most popular third party apps for Reddit, is looking at a cost of $1.7 million per month to continue operating. In contrast, Apollo pays Imgur $166 per month for the same amount of API calls.
This means popular apps like Apollo, Reddit Is Fun, Narwhal and many more will have to shut down, permanently.
Even if you're not a mobile user and don't use any of those apps, this is a step toward killing other ways of customizing Reddit, such as Reddit Enhancement Suite or the use of the desktop interface. More importantly for our visually impaired users, what Reddit is trying to do will most likely mean the end of your continued use of Reddit as a whole. Special third party apps for the visually impaired most likely don't have the kind of cash lying around to pay the API fees to continue on existing.
And believe you me, this isn't only a problem on the user level: many subreddit moderators depend on tools only available outside the official app to keep their communities on-topic and spam-free.


On June 12th, we and a growing number of other subs - large and small - will go dark for at least 48 hours. During that time, you will not be able to view or post any content on /52book. Yes, we might just be a sub full of people with a love of reading, but with over 500 thousands subscribers, we can still do our part, and as such I feel we need to join our fellow subs in making a stand.
As mentioned, many other very popular subreddits are doing the same; some will return after 48 hours: others will go away permanently unless the issue is adequately addressed, since many moderators aren't able to put in the work they do with the poor tools available through the official app or via the website.
This isn't something any of us unpaid moderators do lightly: we do what we do because we love Reddit, and we truly believe this change will make it impossible to keep doing what we love. Shutting down this subreddit for the period mentioned above is really something I hate to do, but I strongly believe that we must take a stand on this topic - and taking the subreddit dark is probably one of the most effective ways available to us to do so.
The two-day blackout isn't the goal, and it certainly isn't the end. Should things reach the 14th with no sign of Reddit choosing to fix what they've broken, we'll use the community and buzz we've built between then and now as a tool for further action.
Even if you're not using a third party app yourself, these changes are likely to impact this and other communities you enjoy as well, with the vast majority of moderation teams relying on third party or self-made tools, that utilise Reddit's API.
And on top of all that, it paints a bleak picture of what is to come for those of us who use other tools, like Reddit Enhancement Suite and


While subs going dark is one thing, regular users can help as well.
Reach out to Reddit via the channels available to you: Modmail /reddit, comment in relevant posts regarding the API changes, submit your comments via the contact forms.
Spread the word about the changes and the consequences where you can. Doesn't have to be on Reddit. The important thing is getting it attention.
Participate in the communities that highlight this issue: /Save3rdPartyApps, /apolloapp, /redditisfun, /getnarwhal/
And finally, stay off Reddit completely from June 12th to 14th. The blackout is one thing, but users staying away from the site entirely will send an equally important message.


Don't be a jerk. As upsetting this may be, threats, profanity and vandalism will be worse than useless in getting people on our side. Please make every effort to be as restrained, polite, reasonable and law-abiding as possible. We're a subreddit full of reasonable people (or at least that's my impression! :) ), so I'm pretty sure we can have an adult discussion about this.
So yeah, I'm leaving this post open for discussion, but as mentioned above, don't be a jerk when commenting. You might not care, but this impacts you directly if you realize it or not.
Just a note to everyone, I basically ripped this whole post from /suggestmeabook mod u/ryushe 's thread post, because they already did a great job, and I'm too tired and lazy to reinvent the wheel.
submitted by not_irish_patrick to 52book [link] [comments]

2023.06.08 11:02 SPGorton New Recovery, New Triggers

[TW: NDEs & abusive family]
Hi all!
I'm 34, last week I made a breakthrough in my self-administered anxiety/depression therapy
My breakthrough came after I went the ptsd route. I fought the perceived stigma of saying I might have ptsd without the X rating traumas.
I put all my tools to following my negative thoughts and tendencies back to two events. Before I was 10 I was almost killed by a friend from behind with a slab of ice and also almost killed by a family member from behind by balling my shirt up and fake pushing me off a cliff.
Now I understand these events from all perspectives thanks to labeling emotions (thanks Adam Driver's TEDtalk!) and forgiving myself.
When it happened it felt like a switch got flipped and after a week I still run excited and overjoyed because my brain is working as intended for maybe the first time in my life.
My current trial I'm handling is family that say it's not ptsd. That I'm wrong. That I'm delusional. That all of my depressed life wouldn't have happened if I didn't drink or smoke weed. Now they guilt me to move back to that small town to "make up for lost time." They say I'm a bad uncle for not being around. I know all of this to be behavior I would have employed just weeks ago if the role were reversed. The only social joy they know is acheived at the expense of others. I used to be like that. But never again.
I just came to share but I'm open for discussion on the best way to digest the garbage my family says to me.
submitted by SPGorton to u/SPGorton [link] [comments]

2023.06.08 11:01 JustEnoughEducation My 10 year hair loss battle is at a crossroads.

Background - I’m 30 years old. Had an FUE transplant on my hairline aged 23. Longterm user of fin/min/niz and recently LLLT laser cap. Transplant has held up but hair loss on non-transplanted areas has progressed and has now become difficult to maintain and conceal.
I’m trying to come to terms with shaving my head and going completely bald. This is a huge step and scares the hell out of me, but I suspect it’s a step I have to do.
Question - what on earth will my recipient area look like shaved down compared to my native hair on the rest of my head? Will the density will be noticeably different on a 0.5 or 0 blade? Will people be able to see that I’ve had a historic transplant on my hairline? Is laser hair removal an option to kill transplanted follicles?
Appreciate your advice. Quite a distressing time for me, my mental health has taken a beating for years due to BDD and hair loss and I need to make a change before I self destruct.
submitted by JustEnoughEducation to tressless [link] [comments]

2023.06.08 11:01 bloodflocd salons in dc/va

i’m moving to the dc area in about a month or two. i’ve been at my current salon for three years now, and while the environment in our salon is pretty nice, i’ve heard horror stories of other salons. i am very nervous about transferring & ending up in a salon with a toxic environment. just wondering if anyone here works at a store in dc or va that could let me know how it is there ?
submitted by bloodflocd to petsmart [link] [comments]

2023.06.08 11:00 cat_acomb Help please!!!

So, for some background: I saved up some money to buy a decent old rv that I thought would be easy to fix over the summer, however I’m moving soon and I want to have it done here in about two weeks, which seems mostly manageable. It’s a 1987 fleetwood prowler, no water damage, and almost everything works… except the fridge. Now known to me as pandoras fridge of hell I am perplexed with an unfortunate situation that could either have a nice solution, or a terribly awful one. This rv was used by the previous owners step daughter, who kind of trashed the place. But I believe with some elbow grease and creativity I can make it into a noble home for myself. My only question is, How do I get an rv fridge out without opening for my blocks health and safety?? (Let me know if you need pictures for a solution)
submitted by cat_acomb to u/cat_acomb [link] [comments]

2023.06.08 11:00 _SkullMaster_ AITA for planting 5 "bombs" in my school

Ok firstly to defend myself, the teacher deserved it , ok lets do the storyyy
Its Monday 5th , 2015 , i am nearly done high school and im getting .REAL. jordans in a few months so i was very excited but then out of nowhere my idiotic little teacher cum's towards me and says i got a E- on my grade, so reasonably i say "BITCH I WORKED HARD FOR MY GRADE YOU CUNT!!!!!!" , the teacher then says hes gonna get me suspended so i ran tf outta there , the school gave my mum a phone call saying im expelled now, so my mum says im not getting the jordans no more, then out of anger i flush her credit card down the toilet..A few days later i come up with a PERFECT plan, i decided to plant exactly 5 bombs in the school staff room, but first i had to search up "how to make boom boom bam's" in safari and it worked!!! , on friday i planted the bomb's in the staff room and ran away, i detonated them as soon as i left the school, over 69,420 people got caught in the explosion!, only 69 died tho :((((, i then found out bombing place's is illegal so i fled the country and started a new life in canada.
View Poll
submitted by _SkullMaster_ to u/_SkullMaster_ [link] [comments]

2023.06.08 10:59 gingerspicefan [Hiring] Sailor Moon Inspired Animation!

Hey everyone!
I am currently looking for a talented animator to make about a minute of animation for a music video I am working on.
The animation would be Sailor Moon inspired and consist of about six scenes. One would be a character walking down the street (looped), one would be them seeing a dog on the street, one would be them picking the dog up, one would be a shot of them with their hair raising, one would be a Sailor Moon-esque transformation scene and one would be them walking away with the dog next to them (looped).
I am open to the budget depending on the quality of work, but ideally I would keep it under $500 USD if possible.
To apply, please supply some examples of your 2D animation and please let me know what kind of budget you'd be looking at!
submitted by gingerspicefan to artcommissions [link] [comments]

2023.06.08 10:59 Ghostyz_ I feel like my friend is being unfair to me

I'm sorry this is long, I just haven't been able to get this off my mind and I don't know who to talk to about this, and I've been listening to some really sad music and its all I've been able to think about because of it. I'm sorry but I'm going to tell you my long story with a friend of mine.
I'll call her A, we met in a friend group, we've been friends for a while now, maybe about 2 years or so, her and I have been really close, essentially best friends. We used to spend nearly every night together and send pictures of things we were doing and do silly things and cute things and those things I'd imagine in romance movies. She was the first girl i really liked, too, and probably not a good sign. We always said goodnight to each other, we'd send pictures of sunsets and sunrises, we sat in silence enjoying each other's company, we played games together and spent lots of time together and were always open to one another, giving reassurance, comfort, and a listening ear if we ever needed one another. All of the nice things, i associate with her. I really love her. She's a wonderful person. Whenever she got jealous or upset, I reassured her that she was still an amazing person.
But she ended up liking me and another one of her friends, long story short, she chose him over me, she spent time with him while deciding on if she wanted him or I, which just felt like an extra punch to the face, and then he invited me to talk with his friend group and it felt like egged me on by saying A would be there. I hated that. I hated that I knew she would pick him over me, I felt so helpless in those few weeks I waited, I felt annoyed that I had to ask her if she made a decision when it felt like it was already made. But I feel guilty for those things, too.
She still wanted to be friends, and I said I did too, because I did, and I wanted to make it work. We didn't really talk for a bit, but she always came back to say she still wanted to be friends and that she didn't want me to leave our friend group. I decided to distance myself and take time for me. Which felt nice, and eventually, I felt a little bit more comfortable to be in our friend group after a while.
she messaged me every now and then that she missed us hanging out. She missed how we used to spend time together at night, or talk about things or just hang out. Which made me upset, I never expressed that with her, I just said I agreed because I did agree. But it felt unfair that she wanted things like this after she chose him over me. it never felt fair to me.
This has happened a few times, where a friend of ours I talk to, we'll call her B, I have some time with her and we enjoy talking and playing games together and hanging out. And Friend A gets jealous of that, I remember a few nights, I called her, and she was crying because she was upset because she thought I'd forget about her and she was scared of losing me because I was spending time with Friend B and was having fun. I felt bad about it, so I comforted her and reassured her I still like spending time with her because I do, I apologized, and she felt guilty about it. I told her I still valued her, and she told me she valued me a lot, too.
This doesn't feel fair to me, I can't become closer with my friends in our friend group, and I just want her to be happy no matter what, I don't want to disrupt her relationship. She wants us to talk like we used to, and she says how she still thinks of me and misses us. I don't want there to be conflict with her and her boyfriend, i don't want her to feel upset or jealous, I just, ahh I don't know, I DON'T KNOW I feel so stressed, and stuck. I still believe she's a good person because she still cares about me and our friends. She's still kindheared and wonderful. I don't want to leave our friendship behind, not friend A or friend B.
I guess TLDR, a friend of mine we used to like each other, she chose him over me, we still wanted to be friends, but i wanted to take time to myself for a bit. She missed me and the things we used to do, we stayed friends, I came back to out friend group, she got jealous and upset of my friend and I spending time together a few times, I reassured her I still like spending time with her, and she said how she misses us. And I feel lost. something like that, I'm sorry if this was a bad TLDR.
I'm sorry this is so long, and if this is disorganized or doesn't make a lot of sense. I just needed to let this off my chest. I'm sorry if it doesn't make sense, I'm sorry I keep saying sorry.
submitted by Ghostyz_ to TrueOffMyChest [link] [comments]

2023.06.08 10:58 Yakut5892 My [21 M] white girlfriend [ 21 F] said that I moved up the social ladder for dating her and I'm lucky for a brown guy.

Okay guys, I'm using a throwaway cause my girlfriend seems to know a lot of people. Sorry, if it's a bit long and winded. Please bear with me.
My girlfriend (Jennifer; not real name) and I are both college students in a mostly white university. It's known for having a great engineering program and thus has an influx of brown South Asian students including me (Mostly male) come in.
Now, I am a Christian Indian born and raised in America, who comes from the stereotypical, traditional family who came to this college for engineering. My girlfriend is white who was apart of a sorority when she started college here for about 2 years until she had to leave due to time commitment issues. I met and started dating her about a year and a half ago when she was in the process of leaving. I had actually started liking here before I knew about her sorority past. (Just putting that out there)
Jennifer still keeps in touch with her sisters and also knows many guys and is still very social. I, on the other hand was nothing like her at all. She is the first girlfriend that I have had. I, like most brown guys it seems, was a shy, socially awkward nerd who didn't know how to talk to girls in the first year. I met a "friend" in one of my classes who seemed to gravitate towards me because I guess he knew I would be willing to help him out in class and help him with homework answers and perhaps he may have used me. I didn't care, because I was willing to do anything to make friends. In return, he invited me to hang out with him and his friends and in a short amount of time he taught me a lot of things when it came to the social scene, parties, clothes, and talking to girls. (I actually was able to get a hand-job from a girl who did it through pity for the most part)
Eventually, I met Jennifer at a party that my friend invited me to. We hit it off and we started dating. Everything is swell. She introduced me to her friends who didn't mind me at first. I introduced her to my friends both white and brown. I still made friends with the brown guys because that's my people, if that makes sense and helped them with their social life.
Now, this happened a few days ago and I haven't seen my girlfriend in person yet. Well, we were both talking about a Greek hosted party that we were invited to and encouraged to invite anyone we could. So, me being a friend wanted to invite a few of my brown friends to the party just as she wanted to invite her own friends. When my gf heard that I was going to invite other brown guys, she came up to me and asked me nicely "Is it alright if you didn't invite your friends?
I asked her why? She said "not all of them, just a few." I asked again which ones? She basically listed off all of my brown friend and none of the white friends that I was planning on inviting. (My list isn't that big btw). We went back and forth about it until she dropped this bomb.
"Well, let's be honest you went up a notch socially since we've been dating. You don't see Indian guys dating white girls like me at all do you? I did agree with her on that part regretfully. My girlfriend is a very hot and attractive girl like most sorority girls and does have guys eyeing her. I guess I agreed, because honestly every brown guy that I have seen with a girlfriend has been either overweight or just not attractive at all and I assume they are settling for a brown guy because no other guy will take them. So, I felt like the luckiest brown guy in the world since dating my girlfriend. I know this makes me a douche bag and I hate the fact I think like this and it doesn't help that Indian men are the least desirable by most women including Indian women :/
Anyways, I told her so are you dating me for some exotic thrill, pity, dare, or because you actually love me? She said "of course I love you. I wouldn't be with you with this long if I didn't". After, some loving words, we had sex and she went back home and we left the question about the friends up in the air. The party isn't for nearly 2 weeks, so there's time.
Now, I don't what to think or position to take from this exchange. On one hand, I feel very hurt emotionally as I could never measure up to my girlfriend especially when another dude could snatch her up easily. I'm also hurt because I am not ashamed of my heritage and should never be, but my girlfriend goes and says this. I love her so much and she may be my first everything for the most part, but I feel so close and understand one another on the same wavelength. I don't know if this could be get in the way of our relationship.
Tldr; My white girlfriend says that I should be lucky for dating her as a brown guy after getting into argument about inviting brown friends to a party and now I don't know how to feel about this and where I should I go from here.
EDIT: Thank you everyone for all of the advice and encouragement I received from you all. I decided I'm going to talk to my girlfriend and ask her about where she sees us in the future. I will also go more in depth for her reason for dating me and her views on brown people. I will make sure I update you all. It'll either be good or bad. I'll let you all know either way.
submitted by Yakut5892 to copypasta [link] [comments]

2023.06.08 10:58 luna_wolf8 PLZ HELP… juvenile leo swollen belly, no stool/urate, not eating, eyes shut. More info below!

PLZ HELP… juvenile leo swollen belly, no stool/urate, not eating, eyes shut. More info below!
I purchased my (I believe possibly female?) leopard gecko on April 20th (not sure of exact hatch date).
Pic 1-3 taken yesterday Pic 4-6 taken 2 days ago Pic 7-8 taken May 27 Pic 9 taken May 9 Pic 10 taken May 4 Last 4 pics taken April 20
Husbandry: -soil/sand mix until replaced with paper towels yesterday -warm side 85°-90° / cool side 75°-78° -humidity kept around 40% -Arcadia shadeweller T5 uvb -halogen bulb for heat during day, ceramic bulb at night -calcium w/o d3 kept in a small cap in her enclosure
Usual diet before current symptoms: -mostly small dubia roaches, silkworms, black soldier fly larvae, crickets (recently stopped feeding crickets and waiting for order of grasshoppers to arrive) - occasionally hornworms, mealworms and small superworms -once a week I offer 3 wax worms as a treat but she doesn’t particularly enjoy them
Important info: - May 4 pic (pic # 10), I was feeding her when one of the bigger dubia roaches that I feed my adult leos fell into her enclosure along with the small one I intended to drop in there. She snatched the big one up before I could get it back out. She acted like she had a hard time swallowing it - pointing her head up to the ceiling and kept opening her mouth. My husband had duty that evening so I was alone with our 5 kids and no vehicle since he drove it to work. Since I was unable to get her to an emergency vet, I did what I had previously read in one of my leopard gecko care sheets which was slowly give her water with a syringe to help her get the dubia down. She eventually got it down and went back to normal. She never seemed to have any issues again, meaning her stools/urates were totally normal and she continued eating the following day or two.
  • May 27th (pic 7 & 8) somewhere in those few days she ceased eating but was still passing regular stools and urate. She was due for a shed very soon so I figured it was due to that.
  • Between May 27th until Tuesday she had begun to appear bloated/thicker around her mid-section and her eyes were usually closed. Her eyes, I assumed may have possibly been due to substrate or shedding so I changed her back to paper towels (also so I could monitor her stool/urate output better). Her eyes are not cloudy and there is no discharge. As of yesterday, she does not lay down completely. She has her lower body completely on the ground, but her upper body, she used her arms to keep herself upright. I also noticed yesterday, her belly appears to have red areas on it whereas before yesterday it was completely translucent with no red areas and no black spots like you see sometimes with juveniles. Her belly is extremely soft, there are no lumps, just little skin rolls which she has always had.
Care Regime: -warm bath daily/every other day while gently massaging her belly from neck to base of tail -flukers eye drops twice a day -water and clear pedialyte via syringe drops twice a day just in case she isn’t using her water dish -carnivore care mixed with calcium & repashy grub pie once a day via syringe started two days ago -bene bac every other day -dose of Panacur (0.03 ml) 3 days ago
My exotic vet is 2 hours away and yesterday I brought my daughter to her pediatrician appt and was unexpectedly given a referral to see a neurologist today 3 hours the opposite way today and I have appts tomorrow and Friday for my other children since I try to make their appts all in the same week. If I need to take her to the vet, I will try to arrange for my mom to come pick her up and bring her there for me but if there is anything else I can do at home for now?
Additional info- I have 3 other leopard geckos. Everyone has their own front open 50 gallon enclosure with warm, cold, and humid hide, plenty of enrichment, fresh bottled water everyday, and everyone else is healthy and normal
submitted by luna_wolf8 to exoticvethelp [link] [comments]

2023.06.08 10:57 throwawaysj92 I'm in love with my best friend of sixteen years.

To my best friend turned boyfriend,
I love you. It's only been two weeks and I've always heard that when you meet the one, you just know.
You've always being my shoulder to lean on. Whether it was through the sudden death of our mutual friend, relationship woes, or any other hardship I've faced, you never wavered. Ever.
The flirting didn't start until a few weeks ago, and honestly it took both of us by surprise since everything has always been platonic between us. And when I kissed you for the first time at the end of my driveway, it felt like a home I never knew I longed for.
Between the late night messages, ranting about season eight of Game of Thrones, and the heated discussions about Avatar: The Last Airbender, a part of me started to feel more than friendship, but we had been friends ever since high school in 2007. I had no idea if you felt the same, so I stayed quiet, wishing you well from afar out of fear of losing the one constant in my life.
My constant. Every time I felt like my world was falling apart, I'd message you and you always responded. You respected my boundaries, and always found a way to cheer me up and build my strength so I could face whatever was being thrown my way at the time.
Then you called me gorgeous, and we took the plunge into something scary and unknown, and wonderfully new.
Sixteen years and five heartbreaks later, here I am in love with my best friend. I can't tell you yet, it's too soon and I'm terrified. But I will tell you eventually. I need to be patient, and do this right because it's YOU.
But I love you. I love your beautiful eyes, and your breathy little chuckle when I snuggle into you. I love how protective you are of the ones you love. I love the silver strands that are starting to grace your hair. I love your sense of humor, and your mind. God, you're so smart. And so handsome.
I love your laugh, and your outer disdain for Disney musicals even though we both know you have all the words memorized. I love your humility, and your kindness. I love the way you hold my hand even in your sleep. I love your smile, and I love that you finally spoke up about how you felt. Otherwise I never would have known this feeling I feel now as I sit in bed and type this.
I love my best friend, and I'm so afraid. But I hope you'll continue to be my shoulder to lean on for sixteen more years and then some. You deserve the world, and I hope by some miracle I can give it to you. I hope I can be your constant like you've been for me.
You're worth the wait, you always have been. And I can't wait to wake up next to my best friend again.
submitted by throwawaysj92 to TrueOffMyChest [link] [comments]

2023.06.08 10:56 luumurusinakeitto He doesn't mind holding my Kindle for me :)

He doesn't mind holding my Kindle for me :) submitted by luumurusinakeitto to kindle [link] [comments]

2023.06.08 10:55 SPGorton New Recovery, New Triggers

[TW: NDEs & abusive family]
Hi all!
I'm 34, last week I made a breakthrough in my self-administered anxiety/depression therapy
My breakthrough came after I went the ptsd route. I fought the perceived stigma of saying I might have ptsd without the X rating traumas.
I put all my tools to following my negative thoughts and tendencies back to two events. Before I was 10 I was almost killed by a friend from behind with a slab of ice and also almost killed by a family member from behind by balling my shirt up and fake pushing me off a cliff.
Now I understand these events from all perspectives thanks to labeling emotions (thanks Adam Driver's TEDtalk!) and forgiving myself.
When it happened it felt like a switch got flipped and after a week I still run excited and overjoyed because my brain is working as intended for maybe the first time in my life.
My current trial I'm handling is family that say it's not ptsd. That I'm wrong. That I'm delusional. That all of my depressed life wouldn't have happened if I didn't drink or smoke weed. Now they guilt me to move back to that small town to "make up for lost time." They say I'm a bad uncle for not being around. I know all of this to be behavior I would have employed just weeks ago if the role were reversed. The only social joy they know is acheived at the expense of others. I used to be like that. But never again.
I just came to share but I'm open for discussion on the best way to digest the garbage my family says to me.
submitted by SPGorton to ptsd [link] [comments]

2023.06.08 10:54 gingerspicefan Sailor Moon Inspired Animation!

Hey everyone!
I am currently looking for a talented animator to make about a minute of animation for a music video I am working on.
The animation would be Sailor Moon inspired and consist of about six scenes. One would be a character walking down the street (looped), one would be them seeing a dog on the street, one would be them picking the dog up, one would be a shot of them with their hair raising, one would be a Sailor Moon-esque transformation scene and one would be them walking away with the dog next to them (looped).
I am open to the budget depending on the quality of work, but ideally I would keep it under $500 USD if possible.
To apply, please supply some examples of your 2D animation and please let me know what kind of budget you'd be looking at!
submitted by gingerspicefan to animation [link] [comments]

2023.06.08 10:53 MatiusRex Level 32 and feeling "Stuck" in progress. Any tips?

Hello Dear community,
I need your help, or, at least I think I do. I've come into a point in the game in which I don't know how to go further. I'll explain; I have gear level 32 (with my special copper mace equipped). I play in a PvE singleplayer world with me myself and I. At this moment, I've killed several V blood targets;
Right now, when I look at my goals, I need to create a Castle Throne, which needs Iron. Another Goal I can set myself is upgrading the Castle heart, which needs glass.
Now it feels like both Iron and Glass are resources which are way out off my league still, with only an equipment level of 32. However, with some smart play, and using wolf form, I was able to sneak near the Iron mine and harvest some Iron. However, for me to be able to create Iron ingots, I need to kill Quincey the Bandit King, which is level 37, a long way from my level 32.
Any tips on how to proceed? Which steps should I take to have a better shot at getting Glass and Iron? Everything felt balanced up until now, but now I feel like a weak little vampire baby.
Thanks in advance!
submitted by MatiusRex to vrising [link] [comments]

2023.06.08 10:52 BeneficialHoneydew96 Committing to Change

I've recently come across this community and it has compelled me to do a significant amount of self-reflection. It didn't necessarily offer me new revelations, but it provided the final push I needed to acknowledge an inconvenient truth: I have been wasting my time gaming.
I have struggled with depression this past school year, and I've used video games as a crutch, despite knowing they don't provide any real relief. Too often, I've found myself neglecting my studies to play games for hours on end. The most troubling part is that I'm not even enjoying the time I spend gaming. There's a constant nagging thought in the back of my mind telling me I'm wasting precious time and falling short of my potential.
However, what really lit a fire under me and sparked my desire to quit gaming entirely was my girlfriend. We've been together for nearly six years, and she's truly phenomenal. We share dreams of a future together and she does so much to help me succeed and reduce my stress. This allows me to focus on my university studies and work towards securing a job that can support us both. But when I play video games, I can't help but feel I'm not holding up my end of the bargain. It's struck me hard: why am I wasting time on games when I could be advancing my studies and securing our future?
I am resolved to change, not only for my own sake but also for the love of my life. I want to give her everything she deserves and more, and I know I can't achieve that by squandering hours each day on something that ultimately doesn't matter.
I am truly grateful to have found this subreddit. Moving forward, I'm considering posting regular accountability updates here.
Sorry if this post seems a bit scattered. I've spent most of the last day gaming, it's almost 4 am now, and I'm dreadfully aware of how much I've set myself back for tomorrow. But, this serves as a reminder of why I must change. And I am committed to doing so, for myself and for the woman I love.
submitted by BeneficialHoneydew96 to StopGaming [link] [comments]

2023.06.08 10:51 No-Seaworthiness2642 Family! COVID long term health impact thread. (high post)

Hello fellows, familia. Grab a coffee/joint/gamersupp.
This is just a public health awareness thread about some little known things amongst the normans. Reddit wont let me post links, but what I will do is post study title and authors/year, and some cases abstract copy paste. I will do at the bottom after the statements.
So, as you all know, COVID is a thing still, and many didn't actually know what it was capable of, outside of comparisons to other coronaviruses and the acute illness. Right now, acute illness is incredibly manageable, but the long term effects on organs is becoming alarming, even in mild cases. So lets take it from the top, so we are on the same page. We will start on organ systems and virus character.
So, covid is pretty much a vascular virus, which seems to disrupt vasculature. Lets start before vaccines to demonstrate to those among us suspicious that the vaccine is the cause. (Its fine to worry about tech, i dont judge).
Every person in Sweden diagnosed with COVID-19 from Feb. 1, 2020, to Sept. 14, 2020 — a total of nearly 87,000 people. Their median age was 48, and 57% were women. Researchers compared them with more than 348,000 Swedish people of similar age and sex who did not have the virus.
In the week after a COVID-19 diagnosis, the risk of a first heart attack increased by three to eight times. The risk of a first stroke caused by a blood clot multiplied by three to six times. In the following weeks, both risks decreased steadily but stayed elevated for at least a month.
Thats PRE vax. In a population which probably have the obesity % of the US and a healthy hiking and outdoor culture. US obesity rate is 40%+. Sweden perhaps half or less. Also, viral load on exposure can be a large determination of severity acutely, but perhaps also viral creep inside the body and the resulting dysfunction and damage.

Risk of Cardiovascular Events after Covid-19: a double-cohort study Objective To determine absolute and relative risks of either symptomatic or asymptomatic SARS-CoV-2 infection for late cardiovascular events and all-cause mortality.
Conclusions Either symptomatic or asymptomatic SARS-CoV-2 infection is associated with increased risk of late cardiovascular outcomes and has causal effect on all-cause mortality in a late post-COVID-19 period
Characteristics of a COVID-19 Cohort With Large Vessel Occlusion: A Multicenter International Study


COVID-19 was an independent predictor of incomplete revascularization and poor outcomes in patients with stroke due to LVO. Patients with COVID-19 with LVO were younger, had fewer cerebrovascular risk factors, and suffered from higher morbidity/mortality rates.
Long-term cardiac pathology in individuals with mild initial COVID-19 illness
In this cohort of selected previously well and home-isolating individuals initially evaluated at a median of 109 days and followed-up at 329 days after diagnosis of COVID-19 infection, respectively, the ongoing cardiac symptoms were related to mild but notable imaging findings, suggesting inflammatory cardiac involvement. At baseline, participants with cardiac symptoms had higher mapping values, suggesting diffuse myocardial inflammation, and more frequent pericardial enhancement, suggesting pericardial inflammatory involvement compared to asymptomatic participants. At follow-up, 53% of the cohort had persistent cardiac symptoms, whereas new symptoms developed in 5%.
Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage
In this study, we investigated the host transcriptome landscape of cardiac tissues collected at rapid autopsy from seven SARS-CoV-2, two pH1N1, and six control patients using targeted spatial transcriptomics approaches. Although SARS-CoV-2 was not detected in cardiac tissue, host transcriptomics showed upregulation of genes associated with DNA damage and repair, heat shock, and M1-like macrophage infiltration in the cardiac tissues of COVID-19 patients. The DNA damage present in the SARS-CoV-2 patient samples, were further confirmed by γ-H2Ax immunohistochemistry.
In comparison, pH1N1 showed upregulation of interferon-stimulated genes, in particular interferon and complement pathways, when compared with COVID-19 patients. These data demonstrate the emergence of distinct transcriptomic profiles in cardiac tissues of SARS-CoV-2 and pH1N1 influenza infection supporting the need for a greater understanding of the effects on extra-pulmonary organs, including the cardiovascular system of COVID-19 patients, to delineate the immunopathobiology of SARS-CoV-2 infection, and long term impact on health.

Great article by British Heart Foundation.

Is coronavirus a disease of the blood vessels?

Updated 12 May 2023
Dr Phoebe Kitscha explores how and why Covid-19 affects the whole circulatory system, and the research that is trying to tackle it.

March 27, 2020

Potential Effects of Coronaviruses on the Cardiovascular SystemA Review

'Coronavirus disease 2019 is associated with a high inflammatory burden that can induce vascular inflammation, myocarditis, and cardiac arrhythmias. Extensive efforts are underway to find specific vaccines and antivirals against SARS-CoV-2. Meanwhile, cardiovascular risk factors and conditions should be judiciously controlled per evidence-based guidelines.'

Long-term cardiovascular outcomes of COVID-19
our results provide evidence that the risk and 1-year burden of cardiovascular disease in survivors of acute COVID-19 are substantial. Care pathways of those surviving the acute episode of COVID-19 should include attention to cardiovascular health and disease.
Acute and postacute sequelae associated with SARS-CoV-2 reinfection
The evidence shows that reinfection further increases risks of death, hospitalization and sequelae in multiple organ systems in the acute and postacute phase. Reducing overall burden of death and disease due to SARS-CoV-2 will require strategies for reinfection prevention.
Long covid: Damage to multiple organs presents in young, low risk patients
Initial data from 201 patients suggest that almost 70% had impairments in one or more organs four months after their initial symptoms of SARS-CoV-2 infection.
SARS-CoV-2 infection and persistence in the human body and brain at autopsy
We show that SARS-CoV-2 is widely distributed, predominantly among patients who died with severe COVID-19, and that virus replication is present in multiple respiratory and non-respiratory tissues, including the brain, early in infection. Further, we detected persistent SARS-CoV-2 RNA in multiple anatomic sites, including throughout the brain, as late as 230 days following symptom onset in one case. Despite extensive distribution of SARS-CoV-2 RNA throughout the body, we observed little evidence of inflammation or direct viral cytopathology outside the respiratory tract. Our data indicate that in some patients SARS-CoV-2 can cause systemic infection and persist in the body for months.

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

SARS-CoV-2 infection primarily affects the pulmonary system, but accumulating evidence suggests that it also affects the pan-vasculature in the extrapulmonary systems by directly (via virus infection) or indirectly (via cytokine storm), causing endothelial dysfunction (endotheliitis, endothelialitis and endotheliopathy) and multi-organ injury.
Mounting evidence suggests that SARS-CoV-2 infection leads to multiple instances of endothelial dysfunction, including reduced nitric oxide (NO) bioavailability, oxidative stress, endothelial injury, glycocalyx/barrier disruption, hyperpermeability, inflammation/leukocyte adhesion, senescence, endothelial-to-mesenchymal transition (EndoMT), hypercoagulability, thrombosis and many others. Thus, COVID-19 is deemed as a (micro)vascular and endothelial disease

Lingering cardiac involvement in previously well people after mild COVID-19

The mild but persistent non-ischemic cardiac inflammation that we describe in this study was not associated with overt structural heart disease or troponin release. Although it is triggered by a viral infection, profound myocardial injury or functional impairment is not typical, contrary to the classical definition of viral myocarditis2. Its pathophysiology is more reminiscent of findings in other chronic diffuse inflammatory syndromes that occur post-virally (for example, human immunodeficiency virus–associated cardiomyopathy)3or as a result of autoimmunity (for example, systemic lupus erythematosus4,5). In these cases, persistent subclinical cardiovascular inflammation seems to predispose people to a poor prognosis and the development of heart failure. Non-ischemic cardiac inflammatory involvement is therefore emerging as an important risk factor, and the long-term prognostic relevance of post-acute COVID-19 cardiac involvement in previously healthy people with mild initial COVID-19 illness requires further investigation.

July 27, 2020

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)

Conclusions and Relevance In this study of a cohort of German patients recently recovered from COVID-19 infection, CMR revealed cardiac involvement in 78 patients (78%) and ongoing myocardial inflammation in 60 patients (60%), independent of preexisting conditions, severity and overall course of the acute illness, and time from the original diagnosis. These findings indicate the need for ongoing investigation of the long-term cardiovascular consequences of COVID-19.

Post-COVID-19 Syndrome

Kamath, Vasantha; Anand, R.1; Radhakrishnan, Buvana1; Markanday, Kushal1
Post-COVID-19 “recovery” cannot be gauged solely on a negative polymerase chain reaction or hospital discharge. There is remarkable variation in the duration, severity, and fluctuation of symptoms, which can affect survivors’ quality of life, functional status, cognition, and mood, and lead to severe disability. Given the global scale of this pandemic, it is apparent that the health-care needs for patients with sequelae of COVID-19 will continue to increase for the foreseeable future.

Immune system deviations?
We heard initial outbreaks of fungal infections of various types. Yes any infection can cause reduction in immune cells. Either because the immune system is busy diverted into tissues, fighting infection, or from apoptosis etc.
The deposits of antigens or viral pieces in many parts of the body, is perhaps causing problems, but also there appears to be markers of T cell exhaustion in some with high PD1 expression on some important immune cells too?
Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines Patients with long-COVID had reduced CD4+ and CD8+ effector memory (EM) cell numbers and increased PD-1 (programmed cell death protein 1) expression on central memory (CM) cells, whereas the asymptomatic participants had reduced CD8+ EM cells only and increased CD28 expression on CM cells. 72% of patients with long COVID who received HRA reported clinical improvement
The risk of pancreatic adenocarcinoma following SARS-CoV family infection
Our findings suggest that pancreatic adenocarcinoma is the most probably malignancy happening after infection with SARS-CoV family
The SARS-CoV-2 E protein induces Toll-like receptor 2-mediated neonatal lung injury in a model of COVID-19 viremia that is rescued by the glucocorticoid ciclesonide
This study provides insight into the pathogenesis of ALI and alveolar remodeling with SARS-CoV-2 viremia in children, whereas revealing the efficacy of steroids.
A new case-control study of Brazilian healthcare workers(HCWs) suggests as many as 27% developed long COVID after infection, and multiple infections raised the risk. The findings were published today in Infection Control & Hospital Epidemiology.
Estimates of the prevalence of long COVID, defined by the Centers for Disease Control and Prevention as new, returning, or lasting symptoms persisting 4 or more weeks after initial COVID-19 infection vary, with some studies showing as many as 43% of infected people will have some lingering symptoms 1 month after COVID-19 confirmation.

"39 (58%) patients (with glioma) experienced tumor progression following COVID-19 infection at a median of 34 days after testing positive for COVID-19.. 22 patients had measurably increased tumor area by a median of 63%; 18 of which constituted hyperprogression; 16 patients developed multifocal disease; 8 developed new nodular enhancement; 3 developed leptomeningeal disease (LMD); and 2 experienced increased infiltrative disease alone. 10 patients’ presentation with new glioma was preceded by COVID-19 infection by a median of 31 days. GBM (glioblastoma) patients represented the majority of progression events, among whom 59% progressed within 60 days of documented infection.. Glioma patients appear to have disease progression at an accelerated pace in the first two months after COVID-19 infection."

SARS-CoV-2 infection: The role of PD-1/PD-L1 and CTLA-4 axis
The most important diagnostic feature in individuals with COVID-19 is lymphocyte depletion, most importantly, T-cells. Due to the induction of interferon-γ (INF-γ) production by neutrophils and monocytes, which are abundantly present in the peripheral blood of the individuals with COVID-19, the expression of inhibitory immune checkpoints including, PD-1 (programmed death), PD-L1 and CTLA4 on the T-cells' surface is enhanced. The purpose of this review is to discuss the functions of these checkpoints and their effects on the dysfunction and exhaustion of T-cells, making them almost ineffective in individuals with COVID-19, especially in the cases with extreme symptoms.

COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males
Mild COVID-19 is associated with mild renal involvement without AKI. Changes in the renal function appear to be related to reduced creatinine clearance and possible albumin leakage in the acute phase of the disease. The reduction in creatinine clearance is not predicted by viral load, and it appears to be a long-term effect of the disease that can last for at least 6 months.

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)
Conclusions: T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted. Non-ICU patients with total T cells counts lower than 800/μL may still require urgent intervention, even in the immediate absence of more severe symptoms due to a high risk for further deterioration in condition.


Cerebral blood flow in patients recovered from mild COVID-19
In this study, lower WM CBF, as well as widespread regional CBF changes identified using quantitative MRI, was found in mild COVID-19 patients. Further studies are needed to determine the reliability of this newly identified COVID-19 brain imaging marker and determine what drives these CBF changes.


Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration

Olivera, Eugenia; Sáez, Albany; Carniglia, Lila; Caruso, Carla; Lasaga, Mercedes; Durand, Daniela*
The present article aimed at reviewing the most recent literature supporting the infectious hypothesis of AD, and addressed the probable risk of developing Alzheimer-like dementia after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, based on evidence linking viral infections and amyloidosis.

Heart-disease risk soars after COVID — even with a mild case

Massive study shows a long-term, substantial rise in risk of cardiovascular disease, including heart attack and stroke, after a SARS-CoV-2 infection.

Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review

This study finds post-COVID-19 condition prevalence is substantial; the health effects of COVID-19 seem to be prolonged and can exert stress on the healthcare system.
Review articleBrain disorders: Impact of mild SARS-CoV-2 may shrink several parts of the brain
Coronavirus (COVID-19) is a highly infectious respiratory infection discovered in Wuhan, China, in December 2019. As a result of the pandemic, several individuals have experienced life-threatening diseases, the loss of loved ones, lockdowns, isolation, an increase in unemployment, and household conflict. Moreover, COVID-19 may cause direct brain injury via encephalopathy. The long-term impacts of this virus on mental healthand brain function need to be analysed by researchers in the coming years. This article aims to describe the prolonged neurological clinical consequences related to brain changes in people with mild COVID-19 infection. When compared to a control group, people those who tested positive for COVID-19 had more brain shrinkage, grey matter shrinkage, and tissue damage. The damage occurs predominantly in areas of the brain that are associated with odour, ambiguity, strokes, reduced attention, headaches, sensory abnormalities, depression, and mental abilities for few months after the first infection. Therefore, in patients after a severe clinical condition of COVID-19, a deepening of persistent neurological signs is necessary.

continuing ...
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2023.06.08 10:51 kelowana The trimster was here. Dallas in her new summer style.

The trimster was here. Dallas in her new summer style.
Dallas is our MainCoon and she is an short haired cat by heart. Not really taking care of her fur and dislikes the brush. So I brush her only short moments and different spots, trying to keep it up, but after a while it’s not really working anymore. In the last years once or twice came the trimster to brush her out, under very active protests! Last year we just had her take it all off and it was such eye opening to see her with short fur. So we decided to do it every year at start of summer. She is an dofus with or without fur, but now the the first two weeks she looks still funny. Thought I share it with you guys.
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2023.06.08 10:50 wahooo92 I [29f] fear weed is ruining our relationship but he [29m] doesn't see it. Am I overreacting?

My partner and I of 6 years are avid stoners. In the past 2 years living together it's developed a bit into a daily habit. We live very successful lives so we figured it's not that bad. I don't drink and he seldom does, once a week or fortnight. Our general rule is we don't smoke during the 9-5 but most evenings and weekends.
However the past year we've been having these weird arguments over nothing. Sometimes I feel like this tenseness in the house and I feel like I have to be perfect and placate my bf or he'll get really upset. Bf says he feels the same vice versa. The other day we had an hour long argument because I didn't say yes to a plan "enthustiacally enough" (bc I was thinking slowly... bc I was high... but he didn't take that). Even being sober in the morning doesnt help much bc I feel there's background irritability from recently being high. I know irritability is a factor bc by the end of the day we both openly crave a joint bc of how annoyed/stressed we are.
However, none of this happens when we're on holiday. Which conveniently is the only time we don't have any weed because we're abroad. On holidays our relationship is as good as ever and I always chalked it up to a lack of stress, but that doesn't explain how this irritability manifests on weekends where we have 0 responsibilities.
It all came to last week. We had just come back from a wonderful holiday week. We unpacked, and then had a small zoot. Within half an hour, tensions were high and I felt like I was walking on eggshells. It's been a week (of daily smoking) and this tension hasn't subsided and yesterday we had an argument bc he didn't hear me say "goodnight love you" and wouldn't take me saying I already said it but nonetheless repeating it louder, he was just adamant I was lying and never initially said it (which apparently means I hate him) and it felt frankly paranoid.
I've brought this up with my bf in a way where I'm not putting faults on any one person, but just said that I noticed that I don't think weed is good for our dynamic and I think it's causing stress and anxiety in both of us. He got really annoyed and said weed didn't affect his judgement and not to "blame weed" for "pissing [him] off". He said this is a way to blame him and absolve myself of culpability for annoying him. He said it has nothing to do with weed and that I'm making correlations where there are none. I pointed out how a few years ago he quit for 3 months as he developed full blown panic issues on weed, and he said they're solved and are adamant they haven't come back.
In the end, I just said I'm personally quitting because I don't think it's conducive to a harmonious house or my own mental health, at least not for now. He got annoyed saying I'm being "extreme" and that I'm "punishing" him for yesterday's argument. I wanna clarify that I don't think weed is a bad drug, but I think our long term abuse of it hasn't been good for us personally.
I want to know if he's right and I'm being unreasonable and blaming it on weed is wrong. Am I being too hard, is it even possible for weed to cause these stress problems? I'm very lost and I hate to lose the only drug I have (I can't even drink caffeine lol), but it's worth it for the relationship, but I'm worried and baffled that it seems like he doesn't think the same.
Tldr: both habitual daily smokers, Ive clocked it may be the root of relationship issues bc we have few problems when sober for extended periods (ie holidays). I think it causes tension and poor critical thinking / relationship management. I've decided to quit for the sake of the relationship, bf thinks I'm being ridiculous and that it's not a problem and that neither of us should quit.
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