Best brake service near me


2023.05.12 19:35 Frances_P042682 CleaningServiceNearMe

Welcome to CleaningServicesNearMe! This subreddit is dedicated to all things related to cleaning services in your local area. Whether you're in need of professional cleaners, looking for recommendations, or interested in sharing your experiences, this community is here to help. Whether you're a homeowner, business owner, or a professional cleaner yourself, this subreddit is the perfect place to discuss everything from deep cleaning to regular maintenance, organization tips, and more.

2021.08.13 08:06 theispfamily Internet Service

Looking for a new internet service provider? Check out our list of providers near you! We've gathered information on the top providers in your area so you can compare and choose the best one for you.

2009.08.05 02:37 MamsTaylor Road Trip!

/roadtrip is your source for everything road trip related. Whether you enjoy traveling by motorcycle, car, or recreational vehicle this is your destination for everything related to road trips!

2023.06.08 10:55 SPGorton New Recovery, New Triggers

[TW: NDEs & abusive family]
Hi all!
I'm 34, last week I made a breakthrough in my self-administered anxiety/depression therapy
My breakthrough came after I went the ptsd route. I fought the perceived stigma of saying I might have ptsd without the X rating traumas.
I put all my tools to following my negative thoughts and tendencies back to two events. Before I was 10 I was almost killed by a friend from behind with a slab of ice and also almost killed by a family member from behind by balling my shirt up and fake pushing me off a cliff.
Now I understand these events from all perspectives thanks to labeling emotions (thanks Adam Driver's TEDtalk!) and forgiving myself.
When it happened it felt like a switch got flipped and after a week I still run excited and overjoyed because my brain is working as intended for maybe the first time in my life.
My current trial I'm handling is family that say it's not ptsd. That I'm wrong. That I'm delusional. That all of my depressed life wouldn't have happened if I didn't drink or smoke weed. Now they guilt me to move back to that small town to "make up for lost time." They say I'm a bad uncle for not being around. I know all of this to be behavior I would have employed just weeks ago if the role were reversed. The only social joy they know is acheived at the expense of others. I used to be like that. But never again.
I just came to share but I'm open for discussion on the best way to digest the garbage my family says to me.
submitted by SPGorton to ptsd [link] [comments]

2023.06.08 10:54 PrudentDetective2234 I got my dream job!!

After years of studying, ups and downs due to my bpd, as well as caring for my mum (she always supported me in following my dreams) It has finally happened! I was job searching for a while I was getting disheartened but it happened.
I just wanted to say don't give up, our road may be harder than others at times but whatever your goal is you can achieve it!
I wish you all the best on your journey xx
submitted by PrudentDetective2234 to BPD [link] [comments]

2023.06.08 10:54 Jimmy1296 Gout Tuber help

Hey guys, struggling to get one been at it about 6 hours total now
Current method: Opal machete Dense Jungle Got a lvl 5 snake hitting me to prevent combat
Is this the best method? Any tips?
submitted by Jimmy1296 to ironscape [link] [comments]

2023.06.08 10:54 websenor0001 Website design company in Udaipur

The top website design company in Udaipur is WebSenor-Infotech, a website design firm. We offer professional web design services at reasonable prices. You can work with us on any type of website development project, and our team members will deliver the greatest outcomes.
WebSenor-Infotech, an Udaipur-based web development company
A web development business in Udaipur is called WebSenor. We are experts in the following fields:
Website Designing:
Have you been looking for a competent and reliable website design company in Udaipur to develop your brand's website? You should not look elsewhere when WebSenor-Infotech is there! We offer comprehensive digital marketing services in and around Udaipur. We can create attractive-looking websites, and we are also capable of rebuilding existing websites in the best possible way. Our expert team analyses the needs of each client before getting into the design process.
Web Development:
We build robust web applications using the latest frameworks like ReactJS, AngularJS, etc., along with modern technologies like HTML5 and CSS3, which deliver fast page load times even on slow network connections.
Website Development:
Offering effective online solutions for your business. Having a good online presence is crucial for businesses in today's digitally connected world. In this case, Websenor is beneficial. We specialized in designing and developing websites that promote products and services, link businesses with customers, and assist businesses in growing. To fully understand your specific needs and goals, our team of experts will work together with you. We'll design a website that is easy for your customers to use, reflects your brand, and works on any device. Furthermore, we'll make sure your website is search engine optimized so that more people can find you online.
Benefits of our web development services include:
Punctual delivery
seasoned developers
responsive for mobile
Maintenance Assistance
WebSenor is one of the top web development firms in Udaipur, with an experienced staff that has been producing high-quality work since 2010. Contact them if you want to learn more about their web development services.
submitted by websenor0001 to u/websenor0001 [link] [comments]

2023.06.08 10:54 HeyPopSmoke [For Hire] Get a Stunning Custom-Built WordPress Website - Unleash Your Online Potential!

Hi there! I'm Dany, a seasoned WordPress developer with over 6 years of experience. Are you ready to take your online presence to the next level? Look no further! I'm here to provide you with an exceptional web development service that will leave your competitors in awe.
Why choose me?
Super-Fast and Modern: Get a website that loads in the blink of an eye, impressing visitors and keeping them engaged.
Custom Made Theme: Stand out from the crowd with a unique and eye-catching design tailored specifically to your brand and target audience.
Seamless Functionality: From custom fields and post types to advanced features like e-commerce and user management, I've got you covered.
Premium Plugins: Enhance your website's capabilities with top-notch plugins that ensure a smooth and hassle-free user experience.
Search Engine Optimization: Boost your online visibility and climb the search engine ranks with expertly implemented SEO techniques.
Social Media + Google Integration: Seamlessly connect your website with social media platforms and harness the power of Google for maximum exposure.
Customer Portal: Experience convenience like never before with a dedicated portal to manage invoices, request changes, sign contracts, and more.
Technical Support: Rest easy knowing that I'll be there to assist you every step of the way, ensuring your website remains in tip-top shape.
Premium Hosting, Custom Domain Name, Secure SSL, and Daily Backups: Your website's security and reliability are my top priorities.
Don't miss out on this offer! Request a quote now and let's turn your online vision into a reality. Visit my portfolio at [link to your portfolio] to see the magic I've created for my clients.
Investment: My rate is $45/hr, with a minimum project cost of $450.
Ready to take the leap? Visit my website to explore the possibilities.
submitted by HeyPopSmoke to forhire [link] [comments]

2023.06.08 10:53 Mamune Replacing my car's compressor along with other parts, having issues with the high pressure switch?

Long story short, I need to replace the bits that make my car cold such as:
I just finished gathering up all the parts last week and left it for service, however the mechanics got in touch through text to tell me that the high pressure switch (should be this one but with different etchings) had issues where it would not turn off the compressor when a certain temperature would be reached.
My question is how common of an issue is this, and do I need to replace any parts? Which part would it be if ever?
Thank you so much, the mechanics have been hard at work on it but maybe I could just get ahead of the problem and replace whichever part is causing the issue in this scenario. Hopefully not the expensive compressor :(
submitted by Mamune to MechanicAdvice [link] [comments]

2023.06.08 10:53 RepresentativeAddict I need a car service for a short trip

Hi, can you please recommend a service that can take me on a short trip? I will be at Chorzów in the next upcoming month and I want to go to Wrocław after 2AM. There will be no trains available at this time. Any service you could recommend? Edit: I'm not saying for rent, i will need someone that will take me from there.
submitted by RepresentativeAddict to poland [link] [comments]

2023.06.08 10:53 MatiusRex Level 32 and feeling "Stuck" in progress. Any tips?

Hello Dear community,
I need your help, or, at least I think I do. I've come into a point in the game in which I don't know how to go further. I'll explain; I have gear level 32 (with my special copper mace equipped). I play in a PvE singleplayer world with me myself and I. At this moment, I've killed several V blood targets;
Right now, when I look at my goals, I need to create a Castle Throne, which needs Iron. Another Goal I can set myself is upgrading the Castle heart, which needs glass.
Now it feels like both Iron and Glass are resources which are way out off my league still, with only an equipment level of 32. However, with some smart play, and using wolf form, I was able to sneak near the Iron mine and harvest some Iron. However, for me to be able to create Iron ingots, I need to kill Quincey the Bandit King, which is level 37, a long way from my level 32.
Any tips on how to proceed? Which steps should I take to have a better shot at getting Glass and Iron? Everything felt balanced up until now, but now I feel like a weak little vampire baby.
Thanks in advance!
submitted by MatiusRex to vrising [link] [comments]

2023.06.08 10:53 KahilSarki Got my first tattoo! (ITYTTMOM)

Got my first tattoo! (ITYTTMOM)
Hello everyone!
I've been listening to Eden since ITYTTMOM came out (2016). Eden has been my #1 artist and rock + roll has been my #1 song on Spotify for the past 6 years! I don't think there's day that's gone by where I haven't heard rock + roll, or something else from this album, or vertigo.
I wasn't in a good place mentally in 2021, and I have to say, Eden might be the only reason I'm still alive. Although I haven't had the money to buy any of his merch or see him live (which is an absolute dream of mine), I wanted to get something for myself that would show how much I love this man and the music that he makes.
This brings me to this subreddit! I saw quite a few people post their tattoos on here, which gave me the motivation to get one too! This is a gift to myself, as a reminder that eventually, everything will be alright. Although I know you're never going to read this, thank you so much for being such an important part of my life, Jon. You are probably one of the best things that has happened to me, and I hope to be able to see you live someday!
'cause I ain't scared of livin'.

(looks shiny because I've put some cream on it - ignore)
submitted by KahilSarki to eden [link] [comments]

2023.06.08 10:53 AscentCareerBoost Supporting Local and African Businesses for Prosperity: Join the Conversation!

Supporting Local and African Businesses for Prosperity: Join the Conversation!
Hey, guys! I want to take a moment to share a personal story that I believe many of you can relate to. I'm a Kenyan, and I've recently faced a challenge that I think many local businesses and entrepreneurs in Africa can relate to – the struggle to gain support and recognition for our products.
You see, I'm an aspiring author and a Career Development profession who has shared some great insights into a book. However, despite my best efforts, the book has had limited sales within local community and the African Market. This experience has made me reflect on the broader issue of how we can support not only local businesses but also African businesses as a whole, helping them thrive and contribute to our shared prosperity.
I'm turning to this engaging community to seek your insights and ideas on this matter. Together, let's brainstorm and discuss strategies to uplift our local and African businesses. How can we, as individuals and as a community, actively support and promote these businesses, enabling them to grow, succeed, and create opportunities for others?
So, what are your thoughts? Have you come across any inspiring stories of individuals or communities who have successfully supported local or African businesses? Do you have any creative ideas or suggestions that could make a tangible difference? I believe that by pooling our diverse experiences and perspectives, we can come up with practical solutions to this shared challenge.
Let's kick-start this conversation and build a platform for empowerment and prosperity. Share your thoughts, experiences, and ideas on how we can support local and African businesses and help them thrive. Together, we can make a real impact!
submitted by AscentCareerBoost to Kenya [link] [comments]

2023.06.08 10:53 West-Garage-9650 Why do I feel like my best friend is jealous of me?

By jealous, I don't mean that kind of hatred or something... It's just I kind of feel like she's jealous of me.
I have a relationship pf more than 10 months and my bsf has been very supporrive of it. But lately as I said she has been distanced towards me, she told me that she heard things about me. She didn't say what and why which made me wondered what wrong did I do. We are still friend, she considers me as her bsf but i feel there's a huge gap between us rn. It's just not the same anymore.
Now before you guys asks me, I have NEVER EVER DISCRIMINATED MY BF WITH HER. We are all classmates, I did everything I could to spend the right amount of time with both of them. She was very close friends with my bf and I didn't mind about it either. I trust them.
And before y'all say that maybe she likes my bf, no she doesn't. She liked my bf's best friend.
My family has been very close to my bf recently and after listening to this my bsf has been like 'omg, you are living your life now', 'if I were you I would be so much happier now', 'I am all left out now', 'yea, you will hangout with your bf now'. She's been like this every time we talk, it's not like she's not happy but she would be like 'I have no one now, I am all along types.
Okay, I get it. It is normal to feel jealous and I'm okay with it but what I am not is how she's reacting to it. I was also jealous of her because she's rich and has been always getting the things she want, going to trips every now and then and what not. But I never reacted like that nor I hated her. I hated myself for being jealous with her but eventually I got over it.
Don't get me wrong, we are very close but idk why from the month of April everything is going wrong.
submitted by West-Garage-9650 to FriendshipAdvice [link] [comments]

2023.06.08 10:53 DullAbbreviations606 Thoughts on how I should build these 2?

Just started playing and really enjoying the game so far. Been reading stuff here a bit, but was looking for input from people who know the game. So any advice would be greatly appreciated.
Picked these 2 up on the 9th day of the game. I thought the farmhand would make a good tank with the traits, even if the stars aren't the best. The squire was cheap and his stats look pretty good to me.
submitted by DullAbbreviations606 to BattleBrothers [link] [comments]

2023.06.08 10:52 BeneficialHoneydew96 Committing to Change

I've recently come across this community and it has compelled me to do a significant amount of self-reflection. It didn't necessarily offer me new revelations, but it provided the final push I needed to acknowledge an inconvenient truth: I have been wasting my time gaming.
I have struggled with depression this past school year, and I've used video games as a crutch, despite knowing they don't provide any real relief. Too often, I've found myself neglecting my studies to play games for hours on end. The most troubling part is that I'm not even enjoying the time I spend gaming. There's a constant nagging thought in the back of my mind telling me I'm wasting precious time and falling short of my potential.
However, what really lit a fire under me and sparked my desire to quit gaming entirely was my girlfriend. We've been together for nearly six years, and she's truly phenomenal. We share dreams of a future together and she does so much to help me succeed and reduce my stress. This allows me to focus on my university studies and work towards securing a job that can support us both. But when I play video games, I can't help but feel I'm not holding up my end of the bargain. It's struck me hard: why am I wasting time on games when I could be advancing my studies and securing our future?
I am resolved to change, not only for my own sake but also for the love of my life. I want to give her everything she deserves and more, and I know I can't achieve that by squandering hours each day on something that ultimately doesn't matter.
I am truly grateful to have found this subreddit. Moving forward, I'm considering posting regular accountability updates here.
Sorry if this post seems a bit scattered. I've spent most of the last day gaming, it's almost 4 am now, and I'm dreadfully aware of how much I've set myself back for tomorrow. But, this serves as a reminder of why I must change. And I am committed to doing so, for myself and for the woman I love.
submitted by BeneficialHoneydew96 to StopGaming [link] [comments]

2023.06.08 10:52 drjigarshahcvts Best Lens Replacement Surgery in Ahmedabad - Cornea Center

Dr. Mehul R Patel is the best contact lens surgeon in Ahmedabad at Cornea Centre. Get your lens replacement surgery with the best eye surgeon in Ahmedabad.
submitted by drjigarshahcvts to u/drjigarshahcvts [link] [comments]

2023.06.08 10:52 Individual-Sky5393 Procedures and conditions for renting a truck: What you need to know before renting a service

When you need to transport large goods, renting a truck is an effective solution to ensure the goods are delivered at the right time and place. However, before hiring this service, you need to understand the procedures and conditions involved to ensure a smooth car rental process. In this article, we will cover what you need to know before hiring a truck service.
Determine your transportation needs: Before renting a truck, clearly define your transportation needs. This includes the quantification of the goods to be shipped, the distance traveled, the specific time and date. This information will help you choose the right vehicle and make specific requirements when renting a service.
Choose a reputable service provider: To ensure the quality of service and the safety of your goods, choose a reputable truck rental service company. It is advisable to learn about the reputation, experience and feedback from previous customers to make the right decision.
Procedure for booking car and contract: Once you have chosen a service provider, you need to carry out the procedure of booking a car and making a contract. Through the contract, make sure that all terms, including price, length of lease, insurance and liability, are clearly noted. Carefully read and understand each term before signing.
Fees and payment methods: Before renting a truck, discuss the cost of the service and payment method with the company providing it. Specify the car rental rate, the cost of lifting goods or other additional services. Be sure to also ask about payment methods, payment times, and any associated deposits.
Insurance conditions: During the truck rental process, be sure to understand the vehicle and cargo insurance conditions. Determine whether the service provider will insure the goods in transit. This will help protect your rights in the event of an accident.
Lease period and adjustment: During the truck rental process, discuss with the company the length of the rental and the possibility of adjustments if there is a change in demand. This allows you to flexibly reschedule your shipping and avoid unnecessary penalty fees.
Before hiring a truck service, it is important to understand the procedures and conditions to ensure the best rental experience and protect your rights. By determining your transportation needs, choosing a reputable company, carrying out procedures and making a careful contract, you can rest assured when using a truck rental service.
With many years of experience in the field of truck rental Vantai24h has built a team of professional, experienced and dedicated staff. Vantai24h's drivers are all professionally trained, have a certified driver's license, and know how to operate trucks safely and effectively.
With a variety of vehicle types and sizes, customers can easily find the right vehicle for their needs. At the same time, Vantai24h is also committed to providing the most complete and quality services to customers, including insurance, experienced drivers, 24/7 customer support services and competitive prices.
In addition, Vantai24h also has a professional truck maintenance and repair system, ensuring that the vehicle is always maintained and repaired regularly to ensure the safety of customers when using.
From the above highlights, Vantai24h has been highly appreciated and trusted by customers as a partner for providing truck rental services. With a commitment to quality and competitive prices, Vantai24h is one of the top choices for those who need to rent a truck for their work.
submitted by Individual-Sky5393 to u/Individual-Sky5393 [link] [comments]

2023.06.08 10:52 Think-Strain69 which academy would be best for module 1?

hello guys i would like to know the best coaching online I can get of Executive module 1. I've appeared for module 2 this june and had took classes from CSCARTINDIA and though it's good they didn't quite meet my expectations and I'm thinking of joining other coaching. Also please suggest me on whether I should be taking online or offline classes
submitted by Think-Strain69 to CompanySecretary [link] [comments]

2023.06.08 10:51 thecursedboi770 Need an online job

Hello there myself an 18 years old boy I'm studying in clg and I want to get my way out of this rat race my parents are in debt due to my educational expenses and I am not able to work as a part time job cause I have tution's and clg so I don't have much time but still can make 3,4hrs a day so an online job is much better and I won't be expecting any salary in exchange for my service all I need is knowledge, information and skills that's all I want you to teach me cause as an owner you much have been more knowledgeable and skilled than me unfortunately I don't have any expertise in any specific thing like digital marketing, email marketing kinda stuff you just tell me how to do and I'll follow your instructions and make the best for you so pls take me in so I want to learn from an actual company or agency owner rahter than those fraud courses and YouTube scammers who are not selling courses or scamming instead working IRL so pls take me in I'll be a trust worthy,hardworker,smart,and consistent worker for ya so pls just give me a chance to prove myself
submitted by thecursedboi770 to MoneyMaking [link] [comments]

2023.06.08 10:51 Griffeminie 8bitdo ultimate 2.4g version doesn't have the hall effect, how is it when it comes to stick drift?

Greetings, recently my ps4 controller did it's service for 3 years and it's got some insane stick drift so I'm trying to find a new controller that I could use for my PC, and then I heard of the 8bitdo ultimate.
Problem however is there's 2 versions of the 8bitdo ultimate, a Bluetooth version and the 2.4g version. The Bluetooth version is way out of my budget with it being 60$ so I have no choice but to go with the 2.4g for 40$.
However, apparently the 2.4g version doesn't have the hall effect thing which is what got me into this controller in the first place.
But I'm willing to try it out as it got features that I actually like such as the back pedals or the d-pad being better than most controllers apparently? but I'm very cautious when it comes to the joysticks as they don't have the hall effect in the 2.4g version
So I'm asking what you guy's experiences are when it comes to the 2.4g version? Mostly play on PC
submitted by Griffeminie to 8bitdo [link] [comments]

2023.06.08 10:51 No-Seaworthiness2642 Family! COVID long term health impact thread. (high post)

Hello fellows, familia. Grab a coffee/joint/gamersupp.
This is just a public health awareness thread about some little known things amongst the normans. Reddit wont let me post links, but what I will do is post study title and authors/year, and some cases abstract copy paste. I will do at the bottom after the statements.
So, as you all know, COVID is a thing still, and many didn't actually know what it was capable of, outside of comparisons to other coronaviruses and the acute illness. Right now, acute illness is incredibly manageable, but the long term effects on organs is becoming alarming, even in mild cases. So lets take it from the top, so we are on the same page. We will start on organ systems and virus character.
So, covid is pretty much a vascular virus, which seems to disrupt vasculature. Lets start before vaccines to demonstrate to those among us suspicious that the vaccine is the cause. (Its fine to worry about tech, i dont judge).
Every person in Sweden diagnosed with COVID-19 from Feb. 1, 2020, to Sept. 14, 2020 — a total of nearly 87,000 people. Their median age was 48, and 57% were women. Researchers compared them with more than 348,000 Swedish people of similar age and sex who did not have the virus.
In the week after a COVID-19 diagnosis, the risk of a first heart attack increased by three to eight times. The risk of a first stroke caused by a blood clot multiplied by three to six times. In the following weeks, both risks decreased steadily but stayed elevated for at least a month.
Thats PRE vax. In a population which probably have the obesity % of the US and a healthy hiking and outdoor culture. US obesity rate is 40%+. Sweden perhaps half or less. Also, viral load on exposure can be a large determination of severity acutely, but perhaps also viral creep inside the body and the resulting dysfunction and damage.

Risk of Cardiovascular Events after Covid-19: a double-cohort study Objective To determine absolute and relative risks of either symptomatic or asymptomatic SARS-CoV-2 infection for late cardiovascular events and all-cause mortality.
Conclusions Either symptomatic or asymptomatic SARS-CoV-2 infection is associated with increased risk of late cardiovascular outcomes and has causal effect on all-cause mortality in a late post-COVID-19 period
Characteristics of a COVID-19 Cohort With Large Vessel Occlusion: A Multicenter International Study


COVID-19 was an independent predictor of incomplete revascularization and poor outcomes in patients with stroke due to LVO. Patients with COVID-19 with LVO were younger, had fewer cerebrovascular risk factors, and suffered from higher morbidity/mortality rates.
Long-term cardiac pathology in individuals with mild initial COVID-19 illness
In this cohort of selected previously well and home-isolating individuals initially evaluated at a median of 109 days and followed-up at 329 days after diagnosis of COVID-19 infection, respectively, the ongoing cardiac symptoms were related to mild but notable imaging findings, suggesting inflammatory cardiac involvement. At baseline, participants with cardiac symptoms had higher mapping values, suggesting diffuse myocardial inflammation, and more frequent pericardial enhancement, suggesting pericardial inflammatory involvement compared to asymptomatic participants. At follow-up, 53% of the cohort had persistent cardiac symptoms, whereas new symptoms developed in 5%.
Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage
In this study, we investigated the host transcriptome landscape of cardiac tissues collected at rapid autopsy from seven SARS-CoV-2, two pH1N1, and six control patients using targeted spatial transcriptomics approaches. Although SARS-CoV-2 was not detected in cardiac tissue, host transcriptomics showed upregulation of genes associated with DNA damage and repair, heat shock, and M1-like macrophage infiltration in the cardiac tissues of COVID-19 patients. The DNA damage present in the SARS-CoV-2 patient samples, were further confirmed by γ-H2Ax immunohistochemistry.
In comparison, pH1N1 showed upregulation of interferon-stimulated genes, in particular interferon and complement pathways, when compared with COVID-19 patients. These data demonstrate the emergence of distinct transcriptomic profiles in cardiac tissues of SARS-CoV-2 and pH1N1 influenza infection supporting the need for a greater understanding of the effects on extra-pulmonary organs, including the cardiovascular system of COVID-19 patients, to delineate the immunopathobiology of SARS-CoV-2 infection, and long term impact on health.

Great article by British Heart Foundation.

Is coronavirus a disease of the blood vessels?

Updated 12 May 2023
Dr Phoebe Kitscha explores how and why Covid-19 affects the whole circulatory system, and the research that is trying to tackle it.

March 27, 2020

Potential Effects of Coronaviruses on the Cardiovascular SystemA Review

'Coronavirus disease 2019 is associated with a high inflammatory burden that can induce vascular inflammation, myocarditis, and cardiac arrhythmias. Extensive efforts are underway to find specific vaccines and antivirals against SARS-CoV-2. Meanwhile, cardiovascular risk factors and conditions should be judiciously controlled per evidence-based guidelines.'

Long-term cardiovascular outcomes of COVID-19
our results provide evidence that the risk and 1-year burden of cardiovascular disease in survivors of acute COVID-19 are substantial. Care pathways of those surviving the acute episode of COVID-19 should include attention to cardiovascular health and disease.
Acute and postacute sequelae associated with SARS-CoV-2 reinfection
The evidence shows that reinfection further increases risks of death, hospitalization and sequelae in multiple organ systems in the acute and postacute phase. Reducing overall burden of death and disease due to SARS-CoV-2 will require strategies for reinfection prevention.
Long covid: Damage to multiple organs presents in young, low risk patients
Initial data from 201 patients suggest that almost 70% had impairments in one or more organs four months after their initial symptoms of SARS-CoV-2 infection.
SARS-CoV-2 infection and persistence in the human body and brain at autopsy
We show that SARS-CoV-2 is widely distributed, predominantly among patients who died with severe COVID-19, and that virus replication is present in multiple respiratory and non-respiratory tissues, including the brain, early in infection. Further, we detected persistent SARS-CoV-2 RNA in multiple anatomic sites, including throughout the brain, as late as 230 days following symptom onset in one case. Despite extensive distribution of SARS-CoV-2 RNA throughout the body, we observed little evidence of inflammation or direct viral cytopathology outside the respiratory tract. Our data indicate that in some patients SARS-CoV-2 can cause systemic infection and persist in the body for months.

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

SARS-CoV-2 infection primarily affects the pulmonary system, but accumulating evidence suggests that it also affects the pan-vasculature in the extrapulmonary systems by directly (via virus infection) or indirectly (via cytokine storm), causing endothelial dysfunction (endotheliitis, endothelialitis and endotheliopathy) and multi-organ injury.
Mounting evidence suggests that SARS-CoV-2 infection leads to multiple instances of endothelial dysfunction, including reduced nitric oxide (NO) bioavailability, oxidative stress, endothelial injury, glycocalyx/barrier disruption, hyperpermeability, inflammation/leukocyte adhesion, senescence, endothelial-to-mesenchymal transition (EndoMT), hypercoagulability, thrombosis and many others. Thus, COVID-19 is deemed as a (micro)vascular and endothelial disease

Lingering cardiac involvement in previously well people after mild COVID-19

The mild but persistent non-ischemic cardiac inflammation that we describe in this study was not associated with overt structural heart disease or troponin release. Although it is triggered by a viral infection, profound myocardial injury or functional impairment is not typical, contrary to the classical definition of viral myocarditis2. Its pathophysiology is more reminiscent of findings in other chronic diffuse inflammatory syndromes that occur post-virally (for example, human immunodeficiency virus–associated cardiomyopathy)3or as a result of autoimmunity (for example, systemic lupus erythematosus4,5). In these cases, persistent subclinical cardiovascular inflammation seems to predispose people to a poor prognosis and the development of heart failure. Non-ischemic cardiac inflammatory involvement is therefore emerging as an important risk factor, and the long-term prognostic relevance of post-acute COVID-19 cardiac involvement in previously healthy people with mild initial COVID-19 illness requires further investigation.

July 27, 2020

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)

Conclusions and Relevance In this study of a cohort of German patients recently recovered from COVID-19 infection, CMR revealed cardiac involvement in 78 patients (78%) and ongoing myocardial inflammation in 60 patients (60%), independent of preexisting conditions, severity and overall course of the acute illness, and time from the original diagnosis. These findings indicate the need for ongoing investigation of the long-term cardiovascular consequences of COVID-19.

Post-COVID-19 Syndrome

Kamath, Vasantha; Anand, R.1; Radhakrishnan, Buvana1; Markanday, Kushal1
Post-COVID-19 “recovery” cannot be gauged solely on a negative polymerase chain reaction or hospital discharge. There is remarkable variation in the duration, severity, and fluctuation of symptoms, which can affect survivors’ quality of life, functional status, cognition, and mood, and lead to severe disability. Given the global scale of this pandemic, it is apparent that the health-care needs for patients with sequelae of COVID-19 will continue to increase for the foreseeable future.

Immune system deviations?
We heard initial outbreaks of fungal infections of various types. Yes any infection can cause reduction in immune cells. Either because the immune system is busy diverted into tissues, fighting infection, or from apoptosis etc.
The deposits of antigens or viral pieces in many parts of the body, is perhaps causing problems, but also there appears to be markers of T cell exhaustion in some with high PD1 expression on some important immune cells too?
Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines Patients with long-COVID had reduced CD4+ and CD8+ effector memory (EM) cell numbers and increased PD-1 (programmed cell death protein 1) expression on central memory (CM) cells, whereas the asymptomatic participants had reduced CD8+ EM cells only and increased CD28 expression on CM cells. 72% of patients with long COVID who received HRA reported clinical improvement
The risk of pancreatic adenocarcinoma following SARS-CoV family infection
Our findings suggest that pancreatic adenocarcinoma is the most probably malignancy happening after infection with SARS-CoV family
The SARS-CoV-2 E protein induces Toll-like receptor 2-mediated neonatal lung injury in a model of COVID-19 viremia that is rescued by the glucocorticoid ciclesonide
This study provides insight into the pathogenesis of ALI and alveolar remodeling with SARS-CoV-2 viremia in children, whereas revealing the efficacy of steroids.
A new case-control study of Brazilian healthcare workers(HCWs) suggests as many as 27% developed long COVID after infection, and multiple infections raised the risk. The findings were published today in Infection Control & Hospital Epidemiology.
Estimates of the prevalence of long COVID, defined by the Centers for Disease Control and Prevention as new, returning, or lasting symptoms persisting 4 or more weeks after initial COVID-19 infection vary, with some studies showing as many as 43% of infected people will have some lingering symptoms 1 month after COVID-19 confirmation.

"39 (58%) patients (with glioma) experienced tumor progression following COVID-19 infection at a median of 34 days after testing positive for COVID-19.. 22 patients had measurably increased tumor area by a median of 63%; 18 of which constituted hyperprogression; 16 patients developed multifocal disease; 8 developed new nodular enhancement; 3 developed leptomeningeal disease (LMD); and 2 experienced increased infiltrative disease alone. 10 patients’ presentation with new glioma was preceded by COVID-19 infection by a median of 31 days. GBM (glioblastoma) patients represented the majority of progression events, among whom 59% progressed within 60 days of documented infection.. Glioma patients appear to have disease progression at an accelerated pace in the first two months after COVID-19 infection."

SARS-CoV-2 infection: The role of PD-1/PD-L1 and CTLA-4 axis
The most important diagnostic feature in individuals with COVID-19 is lymphocyte depletion, most importantly, T-cells. Due to the induction of interferon-γ (INF-γ) production by neutrophils and monocytes, which are abundantly present in the peripheral blood of the individuals with COVID-19, the expression of inhibitory immune checkpoints including, PD-1 (programmed death), PD-L1 and CTLA4 on the T-cells' surface is enhanced. The purpose of this review is to discuss the functions of these checkpoints and their effects on the dysfunction and exhaustion of T-cells, making them almost ineffective in individuals with COVID-19, especially in the cases with extreme symptoms.

COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males
Mild COVID-19 is associated with mild renal involvement without AKI. Changes in the renal function appear to be related to reduced creatinine clearance and possible albumin leakage in the acute phase of the disease. The reduction in creatinine clearance is not predicted by viral load, and it appears to be a long-term effect of the disease that can last for at least 6 months.

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)
Conclusions: T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted. Non-ICU patients with total T cells counts lower than 800/μL may still require urgent intervention, even in the immediate absence of more severe symptoms due to a high risk for further deterioration in condition.


Cerebral blood flow in patients recovered from mild COVID-19
In this study, lower WM CBF, as well as widespread regional CBF changes identified using quantitative MRI, was found in mild COVID-19 patients. Further studies are needed to determine the reliability of this newly identified COVID-19 brain imaging marker and determine what drives these CBF changes.


Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration

Olivera, Eugenia; Sáez, Albany; Carniglia, Lila; Caruso, Carla; Lasaga, Mercedes; Durand, Daniela*
The present article aimed at reviewing the most recent literature supporting the infectious hypothesis of AD, and addressed the probable risk of developing Alzheimer-like dementia after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, based on evidence linking viral infections and amyloidosis.

Heart-disease risk soars after COVID — even with a mild case

Massive study shows a long-term, substantial rise in risk of cardiovascular disease, including heart attack and stroke, after a SARS-CoV-2 infection.

Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review

This study finds post-COVID-19 condition prevalence is substantial; the health effects of COVID-19 seem to be prolonged and can exert stress on the healthcare system.
Review articleBrain disorders: Impact of mild SARS-CoV-2 may shrink several parts of the brain
Coronavirus (COVID-19) is a highly infectious respiratory infection discovered in Wuhan, China, in December 2019. As a result of the pandemic, several individuals have experienced life-threatening diseases, the loss of loved ones, lockdowns, isolation, an increase in unemployment, and household conflict. Moreover, COVID-19 may cause direct brain injury via encephalopathy. The long-term impacts of this virus on mental healthand brain function need to be analysed by researchers in the coming years. This article aims to describe the prolonged neurological clinical consequences related to brain changes in people with mild COVID-19 infection. When compared to a control group, people those who tested positive for COVID-19 had more brain shrinkage, grey matter shrinkage, and tissue damage. The damage occurs predominantly in areas of the brain that are associated with odour, ambiguity, strokes, reduced attention, headaches, sensory abnormalities, depression, and mental abilities for few months after the first infection. Therefore, in patients after a severe clinical condition of COVID-19, a deepening of persistent neurological signs is necessary.

continuing ...
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2023.06.08 10:50 TheLividTechnician Do these people have brainrot? Please, for the love of god, stop making me brake for the sake of being one car ahead on a sliproad...

Do these people have brainrot? Please, for the love of god, stop making me brake for the sake of being one car ahead on a sliproad... submitted by TheLividTechnician to CarTalkUK [link] [comments]

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